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aKRAS Ab
- Development stage
- Preclinical
- Lead developer
- Oblique Therapeutics
- Modality
- Oncolytic Viruses → Oncolytic Therapeutics, Antibody-Based Therapeutics
01
Overview
aKRAS Ab is a preclinical therapeutic candidate being developed by Oblique Therapeutics for the treatment of KRAS-mutated cancers. The program utilizes the company's proprietary **Ab-ra-ca-dab-ra** platform, which is designed to identify high-affinity antibodies against complex or "undruggable" targets by locating hidden epitopes. KRAS has historically been difficult to target with conventional antibodies due to its intracellular localization; however, Oblique's approach involves the development of antibodies that may be delivered via oncolytic viruses to specifically target and inhibit KRAS signaling within tumor cells. As of the latest pipeline updates, the program is in the in-vivo proof-of-concept (POC) stage.
- Other names
- anti-KRAS antibodyaKRAS antibody
02
Targets
KRASG12D (Kirsten rat sarcoma viral oncogene homolog (KRAS) G12D mutant)KRASG12V (KRAS G12V)Kirsten rat sarcoma viral oncogene homolog mutated protein
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