AKT inhibitor X

AKT inhibitor X is a cell-permeable, potent, and selective small molecule inhibitor of AKT (Protein Kinase B). It belongs to a series of phenoxazine derivatives developed for biochemical research to probe the PI3K/AKT/mTOR signaling pathway. The compound functions by inhibiting the phosphorylation and subsequent activation of AKT, which is a critical regulator of cell survival, proliferation, and metabolism. In preclinical oncology research, particularly in breast cancer models, AKT inhibitor X is used to investigate mechanisms of drug resistance and the potential for synergistic effects when combined with other targeted therapies, such as HSP90 inhibitors or apoptosis inducers like isatin-5-sulfonamides. Unlike some other inhibitors in its class, its efficacy in combination regimens can be highly context-dependent, as demonstrated by varying combination index values in hormone-resistant cell lines.

Other names

10-(4'-(N-diethylamino)butyl)-2-chlorophenoxazine hydrochloride10-[4-(diethylamino)butyl]-2-chloro-10H-phenoxazineAKT Inhibitor 10