Drug intelligence / Profile preview

AL-3862 + timolol

Development stage
Preclinical
Lead developer
Alcon
Modality
Small Molecules
Administration
Ophthalmic
01

Overview

AL-3862 + timolol is a combination drug consisting of AL-3862 (a code name for an investigational or less well-characterized compound) and timolol. Timolol is a non-selective beta-adrenergic blocker used primarily to lower intraocular pressure in conditions such as open-angle glaucoma and ocular hypertension. It works by blocking beta(1)-adrenergic receptor in the heart and beta(2)-adrenergic receptor in vascular and bronchial smooth muscle to reduce aqueous humor production within the eye[4][5]. The mechanism of action for AL-3862 is not established from available sources. Combination therapies with timolol are commonly developed to enhance intraocular pressure reduction.

Brand names
Timoptic in OcudoseAzargaCombiganCosoptDuotravXalacom
Other names
dorzolamide hydrochloride + timolol maleate
02

Targets

ADRB2 (β2)ADRB1 (β1)

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