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Al-Cy5.5
- Development stage
- Preclinical
- Lead developer
- Korea University
- Modality
- Small Molecules
- Administration
- Intravenous
01
Overview
Al-Cy5.5 is a novel near-infrared fluorescence (NIRF) emitting molecular imaging probe designed to target atherosclerotic calcification. It is synthesized by chemically coupling alendronate, a bisphosphonate with high affinity for calcium phosphate-containing minerals, to the NIRF dye Cy5.5 via an azide-PEG-NHS ester linker. The probe specifically binds to hydroxyapatite and calcified tissues, allowing for the visualization of spotty vascular calcification, which is a marker of plaque vulnerability. In preclinical murine models, Al-Cy5.5 has demonstrated the ability to selectively target and image calcified atheroma in vivo using high-resolution multichannel intravital molecular imaging systems.
- Other names
- alendronate-Cy5.5alendronate-Cy-5.5alendronate-Cy 5.5alendronate-based near-infrared fluorescence probe
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