Drug intelligence / Profile preview

AL101-PSO

Development stage
Preclinical
Lead developer
Alector
Modality
Small Molecules
Administration
Intravenous, Subcutaneous
01

Overview

AL101-PSO is a botanical drug candidate being developed by AngioLab for the treatment of psoriasis. It is a small molecule-based botanical extract designed to function as a multi-target inhibitor, specifically targeting vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMPs). The mechanism of action involves the inhibition of VEGF-mediated angiogenesis and the suppression of MMP activity, both of which are critical drivers in the pathogenesis of psoriasis, including abnormal microvascular proliferation and tissue remodeling. By modulating these pathways, AL101-PSO aims to reduce the inflammatory response and structural changes characteristic of psoriatic lesions.

02

Targets

PDGF (Platelet-derived Growth Factor family)MMP12 (Macrophage Metalloelastase)VEGFA (Vascular endothelial growth factor A)FGF2

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