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Al18F-TCO-BCMAnano
- Development stage
- Preclinical
- Lead developer
- First Affiliated Hospital of Jinan University
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Nanobodies (VHH) → Antibody Fragments → Engineered Antibody Formats → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
Al18F-TCO-BCMAnano is a preclinical fluorine-18-labeled nanobody-based radiopharmaceutical designed for positron emission tomography (PET) imaging of multiple myeloma. It consists of a high-affinity nanobody (BCMAnano) targeting B-cell maturation antigen (BCMA), which is conjugated to aluminum fluoride-18 (Al18F) via trans-cyclooctene (TCO) click chemistry. Developed by researchers from the First Affiliated Hospital of Jinan University, the Chinese Academy of Medical Sciences, Peking Union Medical College, and Emory University, Al18F-TCO-BCMAnano exhibits high stability and low bone accumulation in vivo, enabling sensitive and specific visualization of BCMA-expressing multiple myeloma lesions.
- Other names
- Al 18F-TCO-BCMAnanoAl18F-TCO-BCMAnanoAl-18F-TCO-BCMAnano
02
Targets
BCMA (B-cell maturation antigen)
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