Drug intelligence / Profile preview

Alahist

Development stage
Unknown
Lead developer
Poly Pharmaceuticals
Modality
Small Molecules
Administration
Oral
01

Overview

Alahist is a brand of over-the-counter (OTC) medications developed by Poly Pharmaceuticals for the symptomatic relief of allergies, the common cold, and cough. The product line includes several formulations such as Alahist IR, Alahist PE, Alahist CF, and Alahist DM. The primary active ingredient across the line is dexbrompheniramine maleate, a first-generation antihistamine that acts as an antagonist at the histamine H1 receptor to reduce symptoms like sneezing, rhinorrhea, and itchy/watery eyes. Depending on the specific formulation, Alahist products may also contain phenylephrine hydrochloride, a decongestant that targets alpha-1 adrenergic receptors, and dextromethorphan hydrobromide, a cough suppressant that acts as a sigma-1 receptor agonist and NMDA receptor antagonist. These medications are marketed for the temporary relief of upper respiratory symptoms associated with hay fever, allergic rhinitis, and the common cold.

Brand names
AlahistAlahist IRAlahist PEAlahist CFAlahist DM
02

Targets

ADRA1A (α1A)SIGMAR1 (Sigma non-opioid intracellular receptor 1)NMDAR (Glutamate receptor ionotropic, NMDA)HRH1 (Histamine H1 Receptor)

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