alarelin acetate microspheres

Alarelin acetate microspheres is a sustained-release formulation of alarelin, a synthetic nonapeptide analog of gonadotropin-releasing hormone (GnRH). Developed by Shanghai Livzon Pharmaceutical, this formulation is designed for subcutaneous injection to provide prolonged therapeutic levels of the drug. As a GnRH receptor agonist, alarelin initially stimulates the pituitary gland to release luteinizing hormone (LH) and follicle-stimulating hormone (FSH). However, continuous administration leads to the downregulation and desensitization of GnRH receptors, resulting in a significant reduction in the production of ovarian steroids. This suppression of estrogen makes it effective for treating hormone-dependent conditions such as endometriosis and estrogen receptor-positive breast cancer in premenopausal women.

Other names

alarelin acetate microspheresalarelin acetate sustained-release microspheres