albaconazole

Albaconazole is a triazole antifungal agent with broad-spectrum activity against pathogenic yeasts, dermatophytes, and filamentous fungi. It acts by inhibiting the fungal enzyme sterol 14α-demethylase (lanosterol 14α-demethylase, CYP51), which is essential for ergosterol biosynthesis in fungal cell membranes. This inhibition leads to the accumulation of toxic methylsterols and disrupts membrane integrity, resulting in fungistatic or fungicidal effects[1][2][6]. Albaconazole has demonstrated high potency in vitro and good oral bioavailability. It was developed as an investigational drug for conditions such as onychomycosis (fungal nail infection), vulvovaginal candidiasis (yeast infection), mycoses, tinea pedis (athlete’s foot), and Chagas disease[3][4][8]. Despite promising preclinical results—including activity against fluconazole-resistant strains—development for these indications has been discontinued[4].

Brand names

Canadiol

Other names

albaconazole