Drug intelligence / Profile preview

albuterol + fluticasone + salmeterol + montelukast + budesonide + formoterol

Development stage
Preclinical
Lead developer
GSK
Modality
Small Molecules
Administration
Inhalation, Oral
01

Overview

This is a combination drug containing six active ingredients commonly used in the management of asthma and chronic obstructive pulmonary disease (COPD): **albuterol**, **fluticasone**, **salmeterol**, **montelukast**, **budesonide**, and **formoterol**. - **Albuterol** is a short-acting beta2-adrenergic agonist (SABA) that acts as a bronchodilator. - **Fluticasone** and **budesonide** are inhaled corticosteroids (ICS) that reduce airway inflammation. - **Salmeterol** and **formoterol** are long-acting beta2-adrenergic agonists (LABA) that maintain bronchial dilation. - **Montelukast** is a leukotriene receptor antagonist, reducing bronchoconstriction and airway inflammation via the cysteinyl leukotriene receptor. No commercial product containing all six agents simultaneously is known or studied; however, combinations of subsets of these agents are routinely used in clinical practice for enhanced asthma control[1][2][4][5][6].

02

Targets

MR (Mineralocorticoid receptor)ADRB2 (β2)GR (Glucocorticoid receptor)ADRB1 (β1)CYSLTR1 (Cysteinyl-leukotriene type 1 receptor)

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