alcohol beverage

Alcohol (ethanol) is utilized as an investigational substance in clinical research sponsored by the Food and Drug Administration (FDA) to study its effects on human psychomotor performance and safety. Specifically, it is used in a Phase 1, randomized, double-blind, crossover study to evaluate the dose-dependent effects of oral Δ9-tetrahydrocannabinol (THC) alone and in combination with alcohol on driving performance and subjective perception in healthy adults. Ethanol acts as a central nervous system depressant, primarily through the positive allosteric modulation of GABA-A receptors and the inhibition of NMDA-type glutamate receptors. In this trial context, the beverage is administered to reach a target blood alcohol concentration (BAC) of 0.08% to assess the safety impact and impairment levels associated with combined cannabis and alcohol consumption.

Other names

ethanolalcoholalcoholic beverage