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aldesleukin + dacarbazine
- Development stage
- Unknown
- Lead developer
- Novartis
- Modality
- Nucleic Acid-Directed Small Molecules → Small Molecules, Covalent Small Molecules → Small Molecules, Cytokines & Interferons → Recombinant Proteins and Enzymes, Classical Binding Small Molecules → Small Molecules
- Administration
- Intravenous
01
Overview
Aldesleukin + dacarbazine is a combination regimen used primarily in the treatment of metastatic melanoma. Aldesleukin is a recombinant analog of interleukin-2 (IL-2), a cytokine that stimulates the proliferation and activation of lymphocytes to induce an adaptive immune response against tumor cells. Dacarbazine is an alkylating agent that interferes with DNA synthesis and function in rapidly dividing cancer cells. The combination leverages both immunostimulatory and cytotoxic mechanisms to enhance antitumor activity in advanced melanoma[4][1][6]. Both agents are associated with significant toxicities and are typically administered under close medical supervision.
- Brand names
- ProleukinDTIC-Dome
- Other names
- recombinant human interleukin-2IL-2IL2IL 2125-L-serine-2-133-interleukin 2 (human reduced)BiocarbazineDacarbazinaDTIC
02
Targets
IL-2R (Interleukin-2/interleukin-15 receptor complex)DNA
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