Drug intelligence / Profile preview

alefacept + betamethasone dipropionate

Development stage
Discontinued
Lead developer
Biogen
Modality
Small Molecules, Fc-Fusion Proteins → Carrier/Scaffold Proteins → Recombinant Proteins and Enzymes
Administration
Intramuscular, Intravenous, Topical
01

Overview

Alefacept + betamethasone dipropionate is a combination therapy used for the treatment of moderate to severe plaque psoriasis. Alefacept is a recombinant fusion protein that binds CD2 and interferes with lymphocyte activation, while betamethasone dipropionate is a topical corticosteroid that helps relieve redness, itching, swelling, and other discomforts caused by psoriasis. The combination aims to provide enhanced therapeutic effect through dual mechanisms of action.

02

Targets

GR (Glucocorticoid receptor)CD2 (T-cell Surface Antigen CD2)

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