alendronic acid + cholecalciferol

Alendronic acid + vitamin D3 is a fixed-dose combination pharmaceutical product used primarily for the treatment of osteoporosis. It combines **alendronic acid**, a nitrogen-containing bisphosphonate, with **cholecalciferol** (vitamin D3). Alendronic acid acts by binding to bone hydroxyapatite and specifically inhibiting the activity of osteoclasts, the cells responsible for bone resorption, thereby increasing bone mineral density and reducing the risk of fractures. Cholecalciferol is a prohormone that is hydroxylated in the body to its active form, calcitriol, which facilitates intestinal calcium absorption and is essential for normal bone mineralization and calcium homeostasis. This combination is designed to ensure that patients receiving bisphosphonate therapy for bone loss also maintain adequate vitamin D levels, which is a common clinical requirement for effective treatment. October Pharma markets a generic version of this combination in the Egyptian market.

Brand names

Fosamax Plus DFosavanceAdrovance

Other names

alendronic acid + vitamin D3alendronate sodium + cholecalciferolalendronate + vitamin D3