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ALEXIS-ISO-1
- Development stage
- Unknown
- Lead developer
- Kiromic BioPharma
- Modality
- Native Immune Cells → Adoptive Cell Transfer → Cell Therapies, CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies
- Administration
- Intravenous
01
Overview
ALEXIS-ISO-1 (also known as Isocel and KB-ISM) is an allogeneic, off-the-shelf gamma delta T-cell therapy engineered to express a chimeric antigen receptor (CAR) targeting isoform 2 of mesothelin (iso-mesothelin). Developed using artificial intelligence by Kiromic BioPharma, this investigational cell therapy is designed for the treatment of solid tumors that express iso-mesothelin. The product leverages healthy donor-derived gamma delta T-cells, which are genetically modified to recognize and attack cancer cells expressing the target antigen. The approach aims to provide a universal CAR-T option for solid malignancies with improved safety, efficacy, and manufacturing scalability compared to autologous therapies[1][5][6][8].
- Brand names
- Isocel
- Other names
- Isomesothelin gamma delta CAR T-cell therapy
02
Targets
Mesothelin
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