Drug intelligence / Profile preview

alfaprostol

Development stage
Preclinical
Lead developer
Xiamen Origin Biotech
Modality
Small Molecules
Administration
Intramuscular
01

Overview

Alfaprostol is a synthetic small molecule analogue of prostaglandin F2α (PGF2α) specifically developed for use in veterinary reproductive medicine. It functions as a potent luteolytic agent by acting as an agonist at the prostaglandin F (FP) receptor. This action induces the regression of the corpus luteum, leading to a rapid decline in systemic progesterone levels and the subsequent initiation of the estrous cycle or the induction of parturition. Developed by Xiamen Origin Biotech, alfaprostol is utilized in livestock species such as cattle, horses, and swine to manage reproductive cycles, synchronize estrus, and treat conditions such as persistent corpus luteum or silent heat.

Other names
18,19,20-trinor-17-cyclohexyl-PGF2α methyl esteralfaprostolum
02

Targets

PTGFR (Prostaglandin F2 alpha receptor)

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