alisol A

**Alisol A** is a natural triterpenoid compound isolated from *Alisma orientale* and is one of the major bioactive constituents of Rhizoma Alismatis, a traditional Chinese medicinal herb. Alisol A exhibits a range of biological activities, most notably **anti-obesity**, **anti-tumor (anti-cancer)** (breast, colorectal), **anti-atherosclerotic**, **hepatoprotective**, and **anti-inflammatory** effects[1][2][3][4][5][6]. Mechanistically, alisol A is a **multi-targeted small molecule**: - It **activates the AMP-activated protein kinase (AMPK)** pathway in tissues including liver, skeletal muscle, and adipose, restoring phosphorylation of AMPK/ACC and suppressing upregulation of SREBP-1c, thus improving lipid and glucose metabolism and insulin sensitivity[4]. - Alisol A additionally **activates SIRT1 (sirtuin 1)** and increases IκBα, thereby inhibiting the proinflammatory transcription factor NF-κB, leading to anti-inflammatory effects[6]. - It acts as a **dual agonist for peroxisome proliferator-activated receptor alpha (PPARα)** and **peroxisome proliferator-activated receptor delta (PPARδ)**, regulating fatty acid synthesis, transport, and oxidation[6]. Alisol A has shown **efficacy in vitro and in vivo** (mouse models), reducing body weight gain, improving hepatic steatosis, enhancing glucose metabolism, and regressing arterial plaques[4][6]. It is currently used as a research compound and is not approved for clinical use—most studies are preclinical, focused on metabolic disease and atherosclerosis[2][3][6][7].

Other names

alisol A(CAS Number: 19885-10-0)