alisol a 24-acetate

**Alisol A 24-acetate** is a protostane-type tetracyclic triterpenoid, one of the main active compounds found in *Rhizoma Alismatis* (tuber of Alisma orientale), a traditional Chinese medicinal herb. It is a natural product with multitarget pharmacological activities, notably **anti-inflammatory, antioxidant, anti-apoptotic, hypolipidemic, and anti-atherosclerotic effects**[1][3][4][5][7]. Mechanistic studies show it inhibits neuroinflammation and apoptosis (via downregulation of microglia and astrocyte proliferation, reduced TNF-α, IL-1β, iNOS, and promotion of PI3K/AKT pathway activity) and suppresses oxidative stress and stimulates autophagy through AMPK/mTOR pathways[1]. Animal studies support its role in **alleviating ischaemic stroke injury (neuroprotection)** and in the **treatment and prevention of obesity** by reducing blood lipids, as well as showing benefit in **osteoarthritis** (inhibition of reactive oxygen species and inflammatory response)[1][3][5]. It may also induce autophagy and apoptosis, potentially contributing to nephrotoxicity, indicating both therapeutic and safety considerations[7]. No pharmaceutical brand names or approved products are recognized; it's primarily studied as a **reference standard**, natural product, or pharmaceutical intermediate in research.

Other names

alisol a 24-acetatealisol a 24-monoacetate24-o-acetylalisol a(8α,9β,14β,23S,24R)-11β,23,25-trihydroxy-24-acetoxydammar-13(17)-en-3-onealisol a 24-o-acetate[4]