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alisol g
- Development stage
- Preclinical
- Modality
- Small Molecules
01
Overview
Alisol G (25-anhydroalisol A) is a natural protostane-type triterpene isolated from the rhizomes of *Alisma orientalis* (Rhizoma Alismatis). It is primarily investigated as a research compound for its diverse pharmacological properties. Mechanistically, it has been shown to inhibit human carboxylesterase 2 (hCE2) and modulate several metabolic and signaling pathways, including the AMPK/ACC/SREBP-1c pathway for anti-obesity effects and the RARα-PPARγ-CD36 cascade for reducing hepatic lipid accumulation. Additionally, it exhibits anti-cancer activity by inactivating PI3K/Akt signaling in colorectal cancer cells and possesses antibacterial properties against Gram-positive bacteria. It is currently not approved for clinical use and is utilized only in preclinical research.
- Other names
- 25-anhydroalisol Aalisol G
02
Targets
CES2 (Carboxylesterase 2)AKT (RAC-alpha serine/threonine-protein kinase)AMPK (Adenosine monophosphate–activated protein kinase)ACC (Acetyl-CoA Carboxylase 1)PPARG (Peroxisome proliferator-activated receptor gamma)PI3K (Phosphoinositide-3-kinase regulatory subunit 6)CD36 (CD36 antigen)RARA (Retinoic acid receptor alpha)SREBP-1 / SREBF1 (SREBP-1)
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