Drug intelligence / Profile preview

Alivio PR

Development stage
Preclinical
Lead developer
PureTech
Modality
Small Molecules
Administration
Oral
01

Overview

Alivio PR is a prolonged-release oral tablet formulation of oxycodone hydrochloride, a small molecule opioid agonist. Developed by Bristol Laboratories, it is designed for the management of moderate to severe chronic pain requiring continuous, around-the-clock opioid analgesia. The drug works by selectively binding to and activating mu-opioid receptors in the central nervous system, thereby inhibiting ascending pain pathways and altering the perception of and response to pain. The prolonged-release delivery system is engineered to provide sustained therapeutic plasma concentrations, allowing for less frequent dosing compared to immediate-release oxycodone products.

Brand names
Alivio PRAlivio Prolonged-Release Tablets
02

Targets

MOR (Mu opioid receptor)

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