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Drug intelligence / Profile preview
alizapride
- Development stage
- Phase 4
- Modality
- Small Molecules
- Administration
- Oral, Intravenous, Intramuscular
01
Overview
Alizapride is a small molecule dopamine antagonist with both prokinetic and antiemetic effects. It is primarily used in the treatment of nausea and vomiting, including postoperative nausea and vomiting, as well as nausea associated with medical procedures, surgeries, and cancer therapies. Its mechanism of action involves antagonism at D2 dopamine receptors in the chemoreceptor trigger zone (CTZ) of the central nervous system, thereby preventing emesis triggered by various stimuli. Structurally related to metoclopramide and other benzamides, alizapride shares similar pharmacological properties. The drug is administered orally or parenterally (IV/IM), has a biological half-life of approximately 3 hours, and is eliminated renally[1][2][4][7].
- Brand names
- LiticanPliticanSuperanVergentan
- Other names
- alizapride hydrochlorideAlizapridaAlizapridumN-((1-allyl-2-pyrrolidinyl)methyl)-6-methoxy-1H-benzotriazole-5-carboxamide
02
Targets
DRD2 (Dopamine D2 Receptor)
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