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ALK TCR-T
- Development stage
- Preclinical
- Lead developer
- ALKemist Bio
- Modality
- TCR-Engineered T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies
- Administration
- Intravenous
01
Overview
ALKemist Bio's ALK TCR-T cell therapy is an investigational adoptive cell therapy designed to treat non-small cell lung cancer (NSCLC) and other solid tumors that express the Anaplastic Lymphoma Kinase (ALK) protein. Unlike traditional CAR-T therapies that typically target surface antigens, this TCR-T approach utilizes engineered T cells to recognize intracellular ALK-derived peptides presented by Major Histocompatibility Complex class I (MHC-I) molecules. This mechanism allows the therapy to target oncogenic drivers that are typically sequestered within the cell and not accessible to antibody-based or CAR-T approaches. The program is currently in the preclinical stage of development and aims to provide a new therapeutic option for patients with ALK-positive solid tumors.
- Other names
- ALKemist Bio ALK TCR-TALKemist Bio ALK TCR-T cell therapy
02
Targets
pMHC (Peptide-MHC complex family)
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