Drug intelligence / Profile preview

ALK1 Follow On Clustering Antibody

Development stage
Preclinical
Lead developer
Diagonal Therapeutics
Modality
Monoclonal Antibodies → Antibody-Based Therapeutics
Administration
Subcutaneous, Intraperitoneal
01

Overview

ALK1 (also known as ALK1 Follow On Clustering Antibody) is a preclinical-stage clustering antibody agonist being developed by Diagonal Therapeutics for the treatment of cardiovascular diseases. Discovered using the company's proprietary DIAGONAL Product Engine, the therapeutic is designed to restore or enhance ALK1 signaling through antibody-mediated receptor clustering. This mechanism of action aims to correct dysregulated vascular signaling pathways that underlie various cardiovascular disorders.

Other names
ALK1ALK-1ALK 1ALK1 Follow-On Clustering AntibodyALK-1 Follow-On Clustering AntibodyALK 1 Follow-On Clustering Antibody
02

Targets

BMPR2 (Bone morphogenetic protein receptor type II)ACVRL1 (Activin receptor-like kinase 1)ACVR2B (Activin receptor type IIB)ACVR2A (Activin receptor type 2A)

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