Drug intelligence / Profile preview

alkylresorcinol extract

Development stage
Unknown
Modality
Small Molecules
Administration
Oral
01

Overview

Alkylresorcinol extract is a concentrated preparation containing **alkylresorcinols (ARs)**, a family of bioactive phenolic lipids found in significant amounts in the bran fractions of cereals, especially wheat and rye[1][3][4]. ARs have a lipophilic polyphenolic structure and vary by side-chain length and functional groups (saturated, unsaturated, and oxo-functionalized). Extracts are typically obtained using methods such as ultrasound-assisted extraction, Soxhlet extraction with acetone, or solvent-assisted maceration, each yielding different profiles of AR homologs[1]. Bioactivity studies demonstrate that these extracts, particularly those enriched in oxidized AR homologs, exhibit **antiproliferative effects against prostate cancer cell lines (PC-3)**, with activity depending on molecular structure and extraction method[1]. The mechanism of action has not been fully characterized, but ARs are considered to interact with cellular membranes and regulate oxidative stress and cellular proliferation[3]. Alkylresorcinol extract is primarily researched as a functional ingredient for foods, nutraceuticals, and dietary supplements.

Other names
AR extractalkylresorcinols extract
02

Targets

Cyp (Cyclophilin family)15-LOX (Lysyl Oxidase)MPO (Myeloperoxidase)SIRT1 (NAD-dependent protein deacetylase sirtuin-1)XO (Xanthine Oxidoreductase)

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