allergen extract from lolium perenne pollen, glutaraldehyde-modified

Allergen extract from lolium perenne pollen, glutaraldehyde-modified is a specific allergoid used in allergen-specific immunotherapy (AIT). Developed by Inmunotek, it is primarily indicated for the treatment of allergic rhinitis, allergic rhinoconjunctivitis, and allergic asthma triggered by perennial ryegrass (*Lolium perenne*) pollen. The glutaraldehyde modification process cross-links the allergen proteins to form high-molecular-weight polymers known as allergoids. This chemical modification significantly reduces the IgE-binding capacity of the allergens, thereby decreasing the risk of immediate allergic reactions and anaphylaxis during administration. Despite the reduced allergenicity, the T-cell epitopes remain preserved, allowing the drug to effectively induce immune tolerance. The mechanism of action involves shifting the immune response from a Th2-dominated profile to a Th1 and regulatory T-cell (Treg) response, characterized by the production of IL-10 and TGF-beta, and an increase in allergen-specific IgG4 blocking antibodies. It is typically administered via subcutaneous injection and is often adsorbed onto aluminum hydroxide to enhance its immunogenic effect.

Brand names

Clustoid

Other names

Lolium perenne allergoidPerennial ryegrass allergoidGlutaraldehyde-modified perennial ryegrass pollen extract