Drug intelligence / Profile preview

Allergoid L-tyrosine adsorbed

Development stage
Unknown
Lead developer
ANALLERGO
Modality
Sublingual Immunotherapy → Allergy Immunotherapy → Therapeutic Vaccines → Vaccines & Immunotherapeutics, Subcutaneous Immunotherapy → Allergy Immunotherapy → Therapeutic Vaccines → Vaccines & Immunotherapeutics
Administration
Subcutaneous
01

Overview

Allergoid L-tyrosine adsorbed is a subcutaneous allergen immunotherapy (AIT) product developed by ANALLERGO for the treatment of respiratory allergies, including allergic rhinitis and asthma. The therapy utilizes allergoids—allergens that have undergone chemical modification (typically via glutaraldehyde) to reduce their IgE-binding capacity, thereby minimizing the risk of immediate allergic reactions during administration. These allergoids are adsorbed onto L-tyrosine, a naturally occurring amino acid that serves as a biodegradable adjuvant. The L-tyrosine adjuvant creates a depot at the injection site, allowing for the slow and sustained release of the allergen, which promotes the induction of peripheral T-cell tolerance, increases the production of protective IgG4 antibodies, and shifts the immune response away from a Th2-dominated allergic profile.

Brand names
Allergoid
Other names
L-tyrosine adsorbed allergoidAllergoid L-Tyrosinesubcutaneous immunotherapy (allergoid, L-tyrosine-adsorbed)
02

Targets

TLR4 (Toll-like receptor 4)TCR (T cell antigen receptor complex)BCR/IgE/IgG (Allergen-specific B-cell receptors and soluble IgE/IgG)

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