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Allergovac depot with Parietaria judaica pollen extract is a subcutaneous immunotherapy (SCIT) product designed for the treatment of allergic rhinoconjunctivitis caused by sensitization to Parietaria judaica pollen. The therapy consists of a build-up phase with increasing doses followed by monthly maintenance injections using a native (non-modified) depot extract of P. judaica pollen. The mechanism of action involves immune modulation through repeated exposure to the allergen, leading to increased production of specific IgG and IgG4 antibodies and decreased cutaneous reactivity and rhinitis symptoms in sensitized individuals. Clinical studies have demonstrated that this product has an adequate safety profile, good tolerability, and preliminary efficacy in reducing allergy symptoms[1][2][5]. It is primarily indicated for patients with seasonal allergic rhinoconjunctivitis due to P. judaica, especially in Mediterranean regions where this weed is prevalent[3].
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