Drug intelligence / Profile preview

Allevx

Development stage
Unknown
Lead developer
Allevion Therapeutics
Modality
Small Molecules
01

Overview

Allevx is a topical analgesic patch formulated with a combination of lidocaine and menthol, primarily indicated for the temporary relief of minor aches and pains associated with arthritis, backache, strains, and sprains. Lidocaine, an amide-type local anesthetic, functions by blocking voltage-gated sodium channels in neuronal membranes, which inhibits the initiation and conduction of pain impulses. Menthol serves as a counterirritant and an agonist of the TRPM8 receptor, inducing a cooling sensation that helps to distract from deeper musculoskeletal discomfort. Developed and distributed by Method Pharmaceuticals, Allevx provides localized treatment with minimal systemic absorption, making it a preferred option for targeted pain management in an over-the-counter (OTC) setting.

Brand names
Allevx
Other names
Lidocaine 4% / Menthol 1% Patch
02

Targets

SCN1A (Voltage-gated sodium channel protein type 1 subunit alpha)TRPM8 (Transient receptor potential cation channel subfamily M member 8)

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