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allium sativum ethyl acetate extract
- Development stage
- Preclinical
- Lead developer
- University of Tunis El Manar
- Modality
- Small Molecules
01
Overview
Allium sativum ethyl acetate extract (EAEAS) is a specialized phytochemical preparation derived from garlic, currently under investigation for its potential as an adjuvant therapy in acute myeloid leukemia (AML). Research indicates that EAEAS exerts potent cytotoxic effects on AML blasts by inducing the intrinsic apoptotic pathway. This mechanism involves mitochondrial membrane depolarization, DNA fragmentation, and the activation of executioner caspases 3 and 7. Furthermore, preliminary evidence suggests that the extract may possess selective activity against leukemia stem cell (LSC) subpopulations, which are often resistant to conventional chemotherapy and responsible for disease relapse. Developed primarily in academic research settings, such as the University of Tunis El Manar, EAEAS represents a natural product-based approach to enhancing treatment outcomes in hematological malignancies.
- Other names
- garlic ethyl acetate extractAllium sativum L. ethyl acetate extract
02
Targets
CASP7 (Caspase-7)CASP3 (Caspase-3)
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