Drug intelligence / Profile preview

allium sativum oil

Development stage
Phase 4
Lead developer
University of Health Sciences Lahore
Administration
Oral, Topical
01

Overview

Allium sativum oil, commonly known as garlic oil, is a botanical extract derived from the bulbs of *Allium sativum*. It contains various organosulfur compounds, such as allicin, diallyl sulfide, and diallyl disulfide, which contribute to its biological activities. In clinical dentistry, it is being investigated as a natural, cost-effective alternative to traditional medicaments like formocresol or mineral trioxide aggregate (MTA) for non-vital pulpotomy in primary teeth, due to its potent antibacterial properties against oral pathogens like *Streptococcus mutans* and *Lactobacillus acidophilus*. Additionally, preclinical research suggests it may have immunomodulatory and anti-inflammatory effects, potentially improving chronic inflammation in hyperlipidemic conditions by modulating T-cell activation and reducing proinflammatory cytokines like TNF-α and IFN-γ via the NF-κB pathway.

Brand names
Garlic OilGarlixGarlicin Cardio
Other names
garlic oilsingle garlic oilessential oil of garlic
02

Targets

NF-κBIFNG (Interferon gamma)TNFA (Tumor necrosis factor alpha (soluble))

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