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ALLLIFE CAR-NK BCMA

Development stage: Unknown
Lead developer: All Life Biotechnology
Modality: CAR-NK Cells → Other Engineered Cells → Adoptive Cell Transfer → Cell Therapies, Lymphokine-Activated Killer Cells → Native Immune Cells → Adoptive Cell Transfer → Cell Therapies
Administration: Intravenous

Overview

ALLLIFE CAR-NK BCMA is an investigational chimeric antigen receptor (CAR) natural killer (NK) cell therapy being developed by All Life Biotechnology for the treatment of multiple myeloma. The therapy utilizes NK cells that have been genetically engineered to express a CAR targeting B-cell maturation antigen (BCMA), a cell surface protein predominantly expressed on malignant plasma cells. Upon recognition of BCMA, the CAR-NK cells mediate direct tumor cell lysis. This modality is designed to offer a targeted therapeutic option with a potentially improved safety profile regarding cytokine release syndrome and neurotoxicity compared to traditional CAR-T cell therapies. It is currently being evaluated in Phase 1/2 clinical trials.

Targets

BCMA (B-cell maturation antigen)

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