Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
allo-aca
- Development stage
- Preclinical
- Lead developer
- Temple University
- Modality
- Modified Peptides → Peptides
- Administration
- Subcutaneous (preclinical), Intraocular (preclinical, Suggested By Stability In Ocular Fluid)
01
Overview
Allo-aca is a **leptin receptor antagonist peptide** and peptidomimetic, designed to potently and specifically block leptin receptor signaling. It has demonstrated picomolar activity in blocking leptin-induced cellular proliferation and signaling in various in vitro systems, as well as antitumor and anti-angiogenic effects in vivo. Allo-aca inhibits leptin-mediated mitogenesis, chemotaxis, and chemokinesis, and can suppress VEGF-dependent expression and activity, making it a candidate for both oncology (notably triple-negative breast cancer) and ophthalmic neovascular diseases. Its biological activity is mediated by strong binding affinity to the leptin receptor (ObR), rendering it a valuable pharmacological tool and potential therapeutic candidate for diseases driven by leptin signaling.
- Other names
- allo-aca
02
Targets
LEPR (Leptin receptor)
Beyond the preview
Go deeper on allo-aca.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on allo-aca.