Allobarbital

Allobarbital is a barbiturate derivative first synthesized in 1912 by Ernst Preiswerk and Ernst Grether at CIBA. It acts as an intermediate‐acting sedative-hypnotic and anticonvulsant, with a pharmacological profile similar to pentobarbital. Allobarbital was primarily used for the treatment of epilepsy (as an anticonvulsant), insomnia, anxiety, and as an adjunct to enhance the effects of analgesics. Its mechanism of action involves positive modulation of the Gamma-aminobutyric acid type A (GABA A) receptor complex in the central nervous system, leading to increased inhibitory neurotransmission and CNS depression. Allobarbital has largely been replaced by newer drugs with improved safety profiles but was used more extensively in some European countries into the 2010s[1][3][5].

Brand names

DialCibalgineDial-Ciba

Other names

allobarbitone5,5-diallylbarbituric aciddiallylbarbitaldiallylbarbitonediallylmalonylureadiallymalum