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allogeneic Adenovirus-specific Cytotoxic T Lymphocytes-Sumithira Vasu-cytomegalovirus infection-adenovirus infection
- Development stage
- Unknown
- Lead developer
- The Ohio State University
- Modality
- Cell Therapies
- Administration
- Intravenous
01
Overview
**Allogeneic adenovirus-specific cytotoxic T lymphocytes** are an investigational adoptive cellular immunotherapy consisting of donor-derived T cells selected or expanded for reactivity against human adenovirus antigens. In the Sumithira Vasu-sponsored NCT03665675 pilot study, these cells are administered intravenously to solid-organ or hematopoietic stem-cell transplant recipients with adenovirus reactivation or disease. The intended mechanism is restoration of pathogen-specific cellular immunity: infused adenovirus-reactive cytotoxic T cells recognize adenovirus antigen-presenting infected cells and mediate cytolytic clearance of infected cells in immunocompromised recipients.
- Other names
- allogeneic adenovirus-specific cytotoxic T lymphocytesdonor adenovirus-specific cytotoxic T lymphocytesdonor AdV-specific CTLs
02
Targets
HAdV (Human adenovirus)
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