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allogeneic bone marrow-derived mesenchymal stem cells (Mayo Clinic)
- Development stage
- Unknown
- Lead developer
- Mayo Clinic
- Modality
- Stem Cell Therapies → Cell Therapies
- Administration
- Intravenous
01
Overview
This investigational cell therapy consists of allogeneic bone marrow-derived mesenchymal stem/stromal cells (BM-MSCs) developed by the Mayo Clinic for the treatment of acute intracerebral hemorrhage (ICH). Administered intravenously, the therapy is designed to leverage the immunomodulatory and regenerative properties of MSCs to mitigate the secondary brain injury that follows a hemorrhagic stroke. Preclinical evidence indicates that these cells can rescue injured neurons and modulate the inflammatory environment. A Phase I dose-escalation trial (NCT03371329) has established the safety and feasibility of this treatment in patients with recent ICH, evaluating doses up to 2 million cells/kg.
- Other names
- BM-MSCsMSChuman allogeneic bone marrow-derived mesenchymal stem/stromal cellsmesenchymal stem cells
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