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Drug intelligence / Profile preview
allogeneic bone marrow-derived multipotent mesenchymal stromal cells
- Development stage
- Phase 1
- Lead developer
- University of Texas Health Science Center at Houston
- Modality
- Stem Cell Therapies → Cell Therapies
- Administration
- Intravenous
01
Overview
This investigational cell therapy consists of allogeneic bone marrow-derived multipotent mesenchymal stromal cells (MSCs) developed by The University of Texas Health Science Center at Houston (UTHealth Houston). It is currently being evaluated in a Phase 1 clinical trial as an adjunctive treatment for patients with treatment-resistant bipolar depression who exhibit elevated levels of C-reactive protein (CRP), a marker of systemic inflammation. The therapy is hypothesized to exert its antidepressant effects by reducing neuro-inflammation and promoting neurogenesis. The cells are harvested from healthy adult donors and manufactured at the Judith R. Hoffberger Cellular Therapeutics Laboratory at UTHealth Houston, an FDA-registered facility.
- Other names
- allogeneic mesenchymal stem cellsMSCs
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