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allogeneic dendritic secretomes
- Development stage
- Unknown
- Modality
- Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems, Recombinant Proteins and Enzymes
- Administration
- Subcutaneous, Intradermal, Intravenous
01
Overview
**Allogeneic dendritic secretomes** is a cell-free biologic preparation derived from the secretomes (secreted factors, including exosomes, cytokines, and proteins) of allogeneic dendritic cells (DCs), designed for immunostimulating and antineoplastic effects. It leverages the paracrine signaling capabilities of DCs to activate antitumor immune responses without the risks associated with live cell therapies, such as graft-versus-host disease. Primarily investigated in oncology, it promotes T-cell activation and immune-mediated tumor killing, with preclinical and early clinical data supporting its use in cancers like glioblastoma and nasopharyngeal carcinoma.[1][5]
- Other names
- allo-dendritic-secretome adjuvant therapy
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