Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
allogeneic hematopoietic stem cell transplant (Columbia University)
- Development stage
- Unknown
- Lead developer
- Columbia University
- Modality
- Stem Cell Therapies → Cell Therapies
- Administration
- Intravenous
01
Overview
This allogeneic hematopoietic stem cell transplantation (HSCT) protocol is being evaluated by Columbia University for the treatment of sickle cell disease and beta thalassemia. The therapeutic approach utilizes a moderately ablative conditioning regimen—comprising busulfan, fludarabine, and alemtuzumab—to prepare the patient's bone marrow for the infusion of healthy hematopoietic stem cells obtained from matched sibling or unrelated donors. By establishing donor chimerism, the procedure aims to replace the patient's defective erythroid lineage with healthy donor cells that produce functional hemoglobin, potentially curing the underlying genetic disorder. The regimen is designed to achieve successful engraftment with reduced toxicity compared to traditional high-dose myeloablative conditioning.
- Other names
- Allogeneic stem cell transplantAllo-HSCTAllogeneic hematopoietic stem cell transplantation
Beyond the preview
Go deeper on allogeneic hematopoietic stem cell transplant (Columbia University).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on allogeneic hematopoietic stem cell transplant (Columbia University).