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allogeneic hematopoietic stem cells (National Cancer Institute, a00c80)
- Development stage
- Unknown
- Lead developer
- National Cancer Institute
- Modality
- Stem Cell Therapies → Cell Therapies
- Administration
- Intravenous
01
Overview
Allogeneic hematopoietic stem cells are donor-derived progenitor cells used in transplantation to treat patients with disorders of T-cell proliferation and/or dysregulation. This investigational approach, led by the National Cancer Institute (NCI), involves the infusion of healthy donor stem cells following a conditioning regimen of either reduced-intensity or immunosuppression-only therapy. The goal is to achieve donor cell engraftment and subsequent reconstitution of a functional, regulated immune system, effectively replacing the patient's dysfunctional T-cell population. This therapy is being evaluated in Phase II clinical trials for its ability to manage severe immune-mediated pathologies, including autoimmunity and lymphoproliferative conditions.
- Other names
- allogeneic hematopoietic cell transplantationallogeneic HCTallogeneic blood or marrow transplant
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