allogeneic human menstrual blood stem cells secretome

Allogeneic human menstrual blood stem cells secretome refers to the cell-free bioactive factors (including extracellular vesicles, exosomes, cytokines, and growth factors) released by mesenchymal stromal/stem cells derived from donated human menstrual blood. This product is administered intravenously and is being investigated for its immunomodulatory and regenerative properties. The mechanism of action involves modulation of immune responses (notably suppression of cytokine storms), reduction of inflammation, promotion of tissue repair, and enhancement of lymphocyte counts. In clinical studies for severe COVID-19 patients, this therapy has shown potential benefits such as improved oxygenation, reduced inflammatory markers (C-reactive protein, ferritin), decreased need for intubation, increased survival rates compared to placebo groups, and improved pulmonary involvement without significant adverse events[1][2][3]. The therapeutic effect is attributed to the paracrine activity—primarily via extracellular vesicles/exosomes—of the MenSCs' secreted factors rather than direct cell engraftment[2]. Preconditioning strategies (e.g., hypoxia or proinflammatory stimuli) can modulate the composition and potency of the secretome[2].

Other names

MenSCs-derived secretomeallogeneic menstrual blood stromal cells secretomeMenSC-derived secretome