allogeneic parathyroid cells

Allogeneic parathyroid cells are an investigative cell therapy designed for the treatment of permanent or refractory hypoparathyroidism. The therapy involves the transplantation of functional parathyroid cells harvested from a donor—typically from patients undergoing surgery for hyperparathyroidism—into a recipient. These transplanted cells function as a biological replacement for the recipient's absent or damaged parathyroid glands, restoring the endogenous production of parathyroid hormone (PTH). By expressing the calcium-sensing receptor (CaSR), the allogeneic cells can physiologically monitor systemic calcium levels and adjust PTH secretion accordingly, which activates parathyroid hormone receptors in the bone and kidneys. This restorative mechanism aims to normalize serum calcium and phosphate levels and reduce or eliminate the patient's dependence on chronic calcium and vitamin D supplementation. To manage immune rejection, various approaches have been explored, including intramuscular transplantation into immunologically favorable sites or the use of immunoprotective encapsulation technologies.

Other names

allogeneic parathyroid cell transplantationallogeneic parathyroid tissueallo-parathyroid cells