allogeneic platelet-rich plasma

Allogeneic platelet-rich plasma (PRP) is a biologic therapy derived from the blood of healthy donors rather than the patient receiving treatment. It consists of plasma with a high concentration of platelets, which are rich in growth factors and cytokines that promote tissue repair and regeneration. Allogeneic PRP is prepared by collecting whole blood or platelets from donors using manual separation or automated apheresis techniques, followed by centrifugation to concentrate the platelets[5]. The resulting product can be activated (e.g., with thrombin and calcium) before application. Mechanistically, allogeneic PRP delivers exogenous growth factors to damaged tissues, stimulating fibroblast proliferation and migration, angiogenesis (formation of new blood vessels), extracellular matrix production, and modulating inflammation[3][4][7]. These effects accelerate wound healing and tissue regeneration. Allogeneic PRP has been investigated for use in chronic wounds (such as diabetic foot ulcers), cartilage injuries, osteoarthritis of the knee/hip[1][5][6][7], and other conditions where autologous PRP may not be feasible due to patient comorbidities or insufficient platelet quality. Current evidence suggests that allogeneic PRP is generally safe with no major adverse events reported in clinical studies; however, its efficacy requires further validation through larger controlled trials[1][8]. Standardization in preparation methods remains an area for improvement.

Other names

allogenic platelet-rich plasmaal-PRPallogenic PRP