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allogeneic side population adipose-derived mesenchymal stem cells

Development stage
Unknown
Lead developer
Tehran University of Medical Sciences
Modality
Stem Cell Therapies → Cell Therapies
Administration
Intrathecal
01

Overview

An investigational allogeneic cell therapy consisting of side population adipose-derived mesenchymal stem cells (SPADMSCs) obtained from volunteer donors. Developed by the Tehran University of Medical Sciences, this therapy is being evaluated for the treatment of spinal muscular atrophy type 1 (SMA type 1), also known as Werdnig-Hoffman disease. SMA type 1 is a severe autosomal recessive neurodegenerative disorder caused by mutations in the SMN1 gene, leading to the loss of alpha motor neurons in the spinal cord. The therapy is administered via intrathecal injection, where the stem cells are hypothesized to provide neurotrophic support and paracrine signaling to protect degenerating motor neurons, potentially slowing disease progression and improving motor function in affected infants.

Other names
SPADMSCsallogeneic adipose-derived mesenchymal stem cellsADMSCsadipose derived mesenchymal stem cell-Tehran University of Medical Sciences-spinal muscular atrophy type 1

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