Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
Allogeneic Stem Cell Transplant-Northwestern University-systemic necrotizing vasculitis-granulomatosis with polyangiitis-eosinophilic granulomatosis with polyangiitis
- Development stage
- Discontinued
- Lead developer
- Northwestern University
- Modality
- Stem Cell Therapies → Cell Therapies
- Administration
- Intravenous
01
Overview
This clinical intervention involves allogeneic hematopoietic stem cell transplantation (allo-HSCT) as a treatment for refractory systemic necrotizing vasculitis and related autoimmune disorders. Conducted at Northwestern University (NCT00278512), the protocol utilizes a high-dose immunosuppressive conditioning regimen—typically including cyclophosphamide, fludarabine, anti-thymocyte globulin (ATG), and alemtuzumab—to ablate the patient's autoreactive immune system. This is followed by the infusion of healthy donor-derived hematopoietic stem cells to reconstitute a functional, non-autoreactive immune system. The therapy is targeted at patients with severe, treatment-resistant forms of granulomatosis with polyangiitis (GPA), eosinophilic granulomatosis with polyangiitis (EGPA), and other necrotizing vasculitides.
- Other names
- Allogeneic Hematopoietic Stem Cell Transplantationallo-HSCTHigh Dose Immune Suppression With Hematopoietic Stem Cell Support
Beyond the preview
Go deeper on Allogeneic Stem Cell Transplant-Northwestern University-systemic necrotizing vasculitis-granulomatosis with polyangiitis-eosinophilic granulomatosis with polyangiitis.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Allogeneic Stem Cell Transplant-Northwestern University-systemic necrotizing vasculitis-granulomatosis with polyangiitis-eosinophilic granulomatosis with polyangiitis.