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allogeneic stool suspension
- Development stage
- Unknown
- Lead developer
- Ulm University
- Modality
- Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
- Administration
- Oral, Rectal
01
Overview
Allogeneic stool suspension is an investigational biological preparation used for fecal microbiota transplantation (FMT). It consists of donor-derived fecal material suspended in a liquid medium for administration to recipients. The preparation is designed to reconstitute the gut microbiota by introducing a complex community of healthy donor microorganisms. It is primarily being studied in the AMIRA trial (NCT04095988) by the University of Ulm for the treatment of diarrhea-predominant irritable bowel syndrome (IBS-D), aiming to restore microbial diversity and improve symptom severity and quality of life.
- Other names
- allogeneic microbiota-reconstitutionfecal microbiota transplantationFMT
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