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allogeneic umbilical cord blood mononuclear cells

Development stage: Unknown
Lead developer: Seventh Medical Center of the People's Liberation Army General Hospital
Modality: Cell Therapies
Administration: Intravenous

Overview

Allogeneic umbilical cord blood mononuclear cells (UCB-MNCs) are a cell therapy product consisting of a diverse population of immune cells, including lymphocytes, monocytes, and progenitor cells, harvested from donor umbilical cord blood. In the context of neonatal care, these cells are being investigated by **The Seventh Medical Center of PLA General Hospital** for the prevention and treatment of bronchopulmonary dysplasia (BPD) in extremely preterm infants. The therapeutic rationale is based on the cells' ability to migrate to injured lung tissue and release a cocktail of anti-inflammatory cytokines and angiogenic factors, thereby mitigating the inflammatory response and supporting alveolar development. Clinical evaluation typically involves intravenous transfusion to assess impact on respiratory support requirements and long-term pulmonary outcomes.

Other names: allogeneic cord blood mononuclear cellsallogeneic UCB-MNCsallogeneic umbilical cord blood transfusion

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