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allogeneic umbilical cord-derived mesenchymal stromal cells
- Development stage
- Phase 1
- Lead developer
- Duke University
- Modality
- Stem Cell Therapies → Cell Therapies
- Administration
- Intravenous, Intraarticular
01
Overview
Allogeneic umbilical cord-derived mesenchymal stromal cells (UC-MSCs) are a cell-based biologic therapy utilizing mesenchymal stromal cells harvested from donor umbilical cord tissue, specifically Wharton's jelly. These cells possess potent immunomodulatory, proangiogenic, and antifibrotic properties, making them candidates for treating a variety of immune-mediated and inflammatory diseases. Their primary mechanism involves the modulation of regulatory T cells (Tregs) and the suppression of pro-inflammatory T-lymphocytes and inflammatory pathways. UC-MSCs are currently being investigated in clinical trials for conditions such as autism spectrum disorder, cerebral palsy, systemic lupus erythematosus, and Crohn's disease-related perianal fistulas.
- Other names
- UC-MSCshuman umbilical cord tissue-derived mesenchymal stromal cellswharton's jelly mesenchymal stromal cells
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