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allogenic adipose-derived mesenchymal stem cells + cholecalciferol
- Development stage
- Unknown
- Lead developer
- Federal University of Rio de Janeiro
- Modality
- Small Molecules, Stem Cell Therapies → Cell Therapies
- Administration
- Intravenous, Oral
01
Overview
This combination therapy consists of allogenic adipose-derived mesenchymal stem cells (ASCs) and oral cholecalciferol (Vitamin D3), currently being investigated by the Universidade Federal do Rio de Janeiro for the treatment of recent-onset type 1 diabetes mellitus. Mesenchymal stem cells are utilized for their potent immunomodulatory and anti-inflammatory properties, which aim to suppress the autoimmune destruction of pancreatic beta-cells and preserve residual insulin production. Cholecalciferol is administered as an adjunct to enhance the regulatory T-cell response and provide synergistic immune modulation. The therapy is typically delivered as a single intravenous infusion of ASCs followed by long-term oral Vitamin D supplementation.
- Other names
- allogenic adipose tissue-derived stromal/stem cells + vitamin DASCs + vitamin DASCs and Vitamin D in Recent-onset Type 1 Diabetes
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