Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
allogenic mesenchymal stem cell-derived exosomes (Isfahan University of Medical Sciences)
- Development stage
- Unknown
- Lead developer
- Isfahan University of Medical Sciences
- Modality
- Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems
- Administration
- Intraarticular
01
Overview
Allogenic mesenchymal stem cell-derived exosomes (MSC-Exos) are an investigational biologic therapy being developed by Isfahan University of Medical Sciences for the treatment of knee osteoarthritis. These exosomes are small (30-150 nm) extracellular vesicles secreted by mesenchymal stem cells that carry a cargo of bioactive molecules, including proteins, lipids, and non-coding RNAs (ncRNAs). When administered via intra-articular injection, they exert therapeutic effects by modulating the immune environment, reducing the expression of pro-inflammatory cytokines, and inhibiting matrix-degrading enzymes such as matrix metalloproteinases (MMPs) and ADAMTS. This paracrine signaling mechanism aims to suppress chondrocyte apoptosis and promote the regeneration of the extracellular matrix and cartilage in the osteoarthritic joint.
- Other names
- MSC-Exosallogenic mesenchymal stem cell-derived exosomesExosomes for Knee Osteoarthritis
02
Targets
MMP12 (Macrophage Metalloelastase)
Beyond the preview
Go deeper on allogenic mesenchymal stem cell-derived exosomes (Isfahan University of Medical Sciences).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on allogenic mesenchymal stem cell-derived exosomes (Isfahan University of Medical Sciences).