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AlloStem
- Development stage
- Preclinical
- Lead developer
- AlloSource
- Modality
- Stem Cell Therapies → Cell Therapies
- Administration
- Implant
01
Overview
**AlloStem** is an AlloSource human cellular bone allograft used as a surgical bone-graft substitute in subtalar arthrodesis. It consists of partially demineralized allogeneic bone matrix seeded with viable adipose-derived mesenchymal stem cells. When implanted at the fusion site with rigid internal fixation, the graft is intended to provide an osteoconductive scaffold, osteoinductive bone-matrix signals, and osteogenic viable cells that support bone formation and fusion. In the randomized AlloStem-versus-autologous-bone-graft subtalar arthrodesis study, 140 patients were enrolled and 124 underwent surgery; CT-based fusion was assessed at 6 months. ([boneandjoint.org.uk](https://boneandjoint.org.uk/Article/10.1302/1358-992X.2024.7.015))
- Brand names
- AlloStem
- Other names
- AlloStem Cellular Bone Allograft
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